MeCP2 as an Activator of Gene Expression

Patricia M. Horvath; Lisa M Monteggia

doi:10.1016/j.tins.2017.11.005

MeCP2 as an Activator of Gene Expression

Patricia M. Horvath, Lisa M Monteggia

Research output: Contribution to journal › Short survey › peer-review

32 Scopus citations

Abstract

Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.

Original language	English (US)
Pages (from-to)	72-74
Number of pages	3
Journal	Trends in Neurosciences
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.tins.2017.11.005
State	Published - Feb 2018

ASJC Scopus subject areas

Neuroscience(all)

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title = "MeCP2 as an Activator of Gene Expression",

abstract = "Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.",

author = "Horvath, {Patricia M.} and Monteggia, {Lisa M}",

note = "Funding Information: This work was supported by National Institutes of Health Grant MH070727 (L.M.M.) and the Division of Basic Sciences Training Program National Institutes of Health Grant T32 GM008203 at UT Southwestern Medical Center (P.M.H.). Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

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AU - Monteggia, Lisa M

N1 - Funding Information: This work was supported by National Institutes of Health Grant MH070727 (L.M.M.) and the Division of Basic Sciences Training Program National Institutes of Health Grant T32 GM008203 at UT Southwestern Medical Center (P.M.H.). Publisher Copyright: © 2017 Elsevier Ltd

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N2 - Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.

AB - Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.

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MeCP2 as an Activator of Gene Expression

Abstract

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