TY - JOUR
T1 - Mechanosensitive channels in the mechanical component of the exercise pressor reflex
AU - Hori, Amane
AU - Fukazawa, Ayumi
AU - Katanosaka, Kimiaki
AU - Mizuno, Masaki
AU - Hotta, Norio
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/12
Y1 - 2023/12
N2 - The cardiovascular response is appropriately regulated during exercise to meet the metabolic demands of the active muscles. The exercise pressor reflex is a neural feedback mechanism through thin-fiber muscle afferents activated by mechanical and metabolic stimuli in the active skeletal muscles. The mechanical component of this reflex is referred to as skeletal muscle mechanoreflex. Its initial step requires mechanotransduction mediated by mechanosensors, which convert mechanical stimuli into biological signals. Recently, various mechanosensors have been identified, and their contributions to muscle mechanoreflex have been actively investigated. Nevertheless, the mechanosensitive channels responsible for this muscular reflex remain largely unknown. This review discusses progress in our understanding of muscle mechanoreflex under healthy conditions, focusing on mechanosensitive channels.
AB - The cardiovascular response is appropriately regulated during exercise to meet the metabolic demands of the active muscles. The exercise pressor reflex is a neural feedback mechanism through thin-fiber muscle afferents activated by mechanical and metabolic stimuli in the active skeletal muscles. The mechanical component of this reflex is referred to as skeletal muscle mechanoreflex. Its initial step requires mechanotransduction mediated by mechanosensors, which convert mechanical stimuli into biological signals. Recently, various mechanosensors have been identified, and their contributions to muscle mechanoreflex have been actively investigated. Nevertheless, the mechanosensitive channels responsible for this muscular reflex remain largely unknown. This review discusses progress in our understanding of muscle mechanoreflex under healthy conditions, focusing on mechanosensitive channels.
KW - Autonomic nervous system
KW - Blood pressure
KW - Cardiovascular responses to exercise
KW - Ion channels
KW - Mechanotransduction
KW - Thin-fiber muscle afferents
UR - http://www.scopus.com/inward/record.url?scp=85175524951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85175524951&partnerID=8YFLogxK
U2 - 10.1016/j.autneu.2023.103128
DO - 10.1016/j.autneu.2023.103128
M3 - Review article
C2 - 37925831
AN - SCOPUS:85175524951
SN - 1566-0702
VL - 250
JO - Autonomic Neuroscience: Basic and Clinical
JF - Autonomic Neuroscience: Basic and Clinical
M1 - 103128
ER -