Abstract
To determine the mechanisms of increase in plasma triacylglycerol concentrations after high dietary intakes of carbohydrates, 10 men with non- insulin-dependent diabetes mellitus (NIDDM) were fed an isoenergetic high- carbohydrate diet (55% of energy as carbohydrate and 30% as fat) and a high- monounsaturated-fat diet (45% of energy as fat and 40% as carbohydrates) for 6 wk in a randomized, crossover manner. The high carbohydrate diet raised fasting plasma triacylglycerol concentrations by 26% (P = 0.007) but did not affect postheparin lipoprotein lipase (P = 0.2) or hepatic lipase activities (P = 0.9). The oral-fat-tolerance test labeled with retinyl palmitate also revealed no differences in postprandial plasma triacylglycerol (P = 0.37) or retinyl palmitate clearances (P = 0.34) between the two diets. We conclude that the increase in plasma triacylglycerol concentrations with high- carbohydrate diets in men with NIDDM is not due to reduced lipolysis or diminished postprandial clearance of triacylglycerol-rich lipoproteins but is primarily due to increased hepatic secretion of very-low-density- lipoprotein, triacylglycerols.
Original language | English (US) |
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Pages (from-to) | 996-1002 |
Number of pages | 7 |
Journal | American Journal of Clinical Nutrition |
Volume | 62 |
Issue number | 5 |
DOIs | |
State | Published - Nov 1995 |
Keywords
- Dietary carbohydrates
- chylomicrons
- hepatic lipase
- lipoprotein lipase
- lipoproteins
- monounsaturated fatty acids
- noninsulin-dependent diabetes mellitus
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics