Measuring the Full-Field Electroretinogram in Rodents

Pei Ying Lee, Da Zhao, Vickie H.Y. Wong, Anh Hoang, Katie K.N. Tran, Anna K. van Koeverden, Brianna C. Afiat, Christine T.O. Nguyen, Bang V. Bui

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Electroretinography allows for noninvasive functional assessment of the retina and is a mainstay for preclinical studies of retinal function in health and disease. The full-field electroretinogram is useful for a variety of applications as it returns a functional readout from each of the major cell classes within the retina: photoreceptors, bipolar cells, amacrine cells, and retinal ganglion cells. Rodent models are commonly employed in ocular degeneration studies due to the fast throughput of these mammalian species and the conservation of the electroretinogram from the preclinic to the clinic. Here we describe approaches for in vivo electroretinography in rodent models.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages131-140
Number of pages10
DOIs
StatePublished - 2023
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume2708
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Electroretinogram
  • In vivo retinal assessment
  • Retinal function
  • Rodents
  • Small animal models

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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