TY - JOUR
T1 - Measurement of exhaled nitric oxide by three different techniques
AU - Robbins, Richard A.
AU - Floreani, Anthony A.
AU - Von Essen, Susanna G.
AU - Sisson, Joseph H.
AU - Hill, Gary E.
AU - Rubinstein, Israel
AU - Townley, Robert G.
PY - 1996
Y1 - 1996
N2 - The purpose of the study was to compare exhaled nitric oxide (NO) determined by three techniques. Ninety-one subjects performed a slow vital capacity maneuver: (1) through the mouth directly into a NO chemiluminescence analyzer (peak oral NO), (2) through the mouth into a collection bag (mean oral NO), and (3) through the nose into a collection bag (mean nasal NO). Peak oral NO was higher in patients with asthma (n = 18, 174.2 ± 27.0 ppb), but lower in smokers (n = 36, 39.6 ± 4.8 ppb) compared with nonsmoking control subjects (n = 23, 105.5 ± 8.4 ppb, p < 0.05 both comparisons). Mean oral NO levels were significantly lower than peak oral NO levels (p < 0.05), but still higher in patients with asthma in comparison with nonsmoking healthy control subjects and asymptomatic smokers (27.2 ± 3.5 versus 14.5 ± 1.1 and 7.3 ± 0.7 ppb, respectively, p < 0.05). In contrast, there was no significant difference in mean nasal NO levels between the three groups. Peak oral NO and mean oral NO levels correlated (r = 0.772, p < 0.0001). Determination of exhaled oral NO levels is qualitatively independent of the technique used, but nasal exhalation may affect NO determination in conditions associated with airway inflammation.
AB - The purpose of the study was to compare exhaled nitric oxide (NO) determined by three techniques. Ninety-one subjects performed a slow vital capacity maneuver: (1) through the mouth directly into a NO chemiluminescence analyzer (peak oral NO), (2) through the mouth into a collection bag (mean oral NO), and (3) through the nose into a collection bag (mean nasal NO). Peak oral NO was higher in patients with asthma (n = 18, 174.2 ± 27.0 ppb), but lower in smokers (n = 36, 39.6 ± 4.8 ppb) compared with nonsmoking control subjects (n = 23, 105.5 ± 8.4 ppb, p < 0.05 both comparisons). Mean oral NO levels were significantly lower than peak oral NO levels (p < 0.05), but still higher in patients with asthma in comparison with nonsmoking healthy control subjects and asymptomatic smokers (27.2 ± 3.5 versus 14.5 ± 1.1 and 7.3 ± 0.7 ppb, respectively, p < 0.05). In contrast, there was no significant difference in mean nasal NO levels between the three groups. Peak oral NO and mean oral NO levels correlated (r = 0.772, p < 0.0001). Determination of exhaled oral NO levels is qualitatively independent of the technique used, but nasal exhalation may affect NO determination in conditions associated with airway inflammation.
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U2 - 10.1164/ajrccm.153.5.8630613
DO - 10.1164/ajrccm.153.5.8630613
M3 - Article
C2 - 8630613
AN - SCOPUS:0029940578
SN - 1073-449X
VL - 153
SP - 1631
EP - 1635
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 5
ER -