Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life

Ousseny Zerbo; G. Thomas Ray; Bruce Fireman; Evan Layefsky; Kristin Goddard; Edwin Lewis; Pat Ross; Saad Omer; Mara Greenberg; Nicola P. Klein

doi:10.1038/s41467-023-36547-4

Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life

Ousseny Zerbo, G. Thomas Ray, Bruce Fireman, Evan Layefsky, Kristin Goddard, Edwin Lewis, Pat Ross, Saad Omer, Mara Greenberg, Nicola P. Klein

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We examined the effectiveness of maternal vaccination against SARS-CoV-2 infection in 30,311 infants born at Kaiser Permanente Northern California from December 15, 2020, to May 31, 2022. Using Cox regression, the effectiveness of ≥2 doses of COVID-19 vaccine received during pregnancy was 84% (95% confidence interval [CI]: 66, 93), 62% (CI: 39, 77) and 56% (CI: 34,71) during months 0–2, 0–4 and 0- 6 of a child’s life, respectively, in the Delta variant period. In the Omicron variant period, the effectiveness of maternal vaccination in these three age intervals was 21% (CI: −21,48), 14% (CI: −9,32) and 13% (CI: −3,26), respectively. Over the entire study period, the incidence of hospitalization for COVID-19 was lower during the first 6 months of life among infants of vaccinated mothers compared with infants of unvaccinated mothers (21/100,000 person-years vs. 100/100,000 person-years). Maternal vaccination was protective, but protection was lower during Omicron than during Delta. Protection during both periods decreased as infants aged.

Original language	English (US)
Article number	894
Journal	Nature communications
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41467-023-36547-4
State	Published - Dec 2023
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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title = "Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life",

abstract = "We examined the effectiveness of maternal vaccination against SARS-CoV-2 infection in 30,311 infants born at Kaiser Permanente Northern California from December 15, 2020, to May 31, 2022. Using Cox regression, the effectiveness of ≥2 doses of COVID-19 vaccine received during pregnancy was 84% (95% confidence interval [CI]: 66, 93), 62% (CI: 39, 77) and 56% (CI: 34,71) during months 0–2, 0–4 and 0- 6 of a child{\textquoteright}s life, respectively, in the Delta variant period. In the Omicron variant period, the effectiveness of maternal vaccination in these three age intervals was 21% (CI: −21,48), 14% (CI: −9,32) and 13% (CI: −3,26), respectively. Over the entire study period, the incidence of hospitalization for COVID-19 was lower during the first 6 months of life among infants of vaccinated mothers compared with infants of unvaccinated mothers (21/100,000 person-years vs. 100/100,000 person-years). Maternal vaccination was protective, but protection was lower during Omicron than during Delta. Protection during both periods decreased as infants aged.",

author = "Ousseny Zerbo and Ray, {G. Thomas} and Bruce Fireman and Evan Layefsky and Kristin Goddard and Edwin Lewis and Pat Ross and Saad Omer and Mara Greenberg and Klein, {Nicola P.}",

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AU - Goddard, Kristin

AU - Lewis, Edwin

AU - Ross, Pat

AU - Omer, Saad

AU - Greenberg, Mara

AU - Klein, Nicola P.

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Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life

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