TY - JOUR
T1 - Maternal hypertensive disorders and survival without major morbidities among extremely low gestation newborns
AU - Generic Database Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
AU - Kole-White, Martha B.
AU - Saha, Shampa
AU - Werner, Erika F.
AU - Chawla, Sanjay
AU - Keszler, Martin
AU - McGowan, Elisabeth C.
AU - Wyckoff, Myra H.
AU - Laptook, Abbot R.
AU - Wyckoff, Myra
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2023/4
Y1 - 2023/4
N2 - Objective: Evaluate if odds of survival without major morbidity are higher among extremely low gestation neonates (ELGANs) born to mothers with chronic hypertension (cHTN) or hypertensive disorders of pregnancy (HDP) compared to ELGANs born to mothers without hypertension (HTN). Study design: Retrospective study of prospectively collected data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Included children had a birthweight of 401–1000 g and/or gestational age of 220/7 to 286/7 wks. The primary outcome was survival to discharge without major morbidity. Multivariable regression models were used to compare outcomes among ELGANs born to women with cHTN, HDP, and no HTN. Results: Survival without morbidities for newborns of mothers with no HTN, cHTN and HDP (29.1%, 32.9%, 37.0% respectively) did not differ after adjustment. Conclusion: After adjusting for contributing variables maternal HTN is not associated with improved survival free of morbidity among ELGANs. Trials Registration: clinicaltrials.gov
AB - Objective: Evaluate if odds of survival without major morbidity are higher among extremely low gestation neonates (ELGANs) born to mothers with chronic hypertension (cHTN) or hypertensive disorders of pregnancy (HDP) compared to ELGANs born to mothers without hypertension (HTN). Study design: Retrospective study of prospectively collected data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Included children had a birthweight of 401–1000 g and/or gestational age of 220/7 to 286/7 wks. The primary outcome was survival to discharge without major morbidity. Multivariable regression models were used to compare outcomes among ELGANs born to women with cHTN, HDP, and no HTN. Results: Survival without morbidities for newborns of mothers with no HTN, cHTN and HDP (29.1%, 32.9%, 37.0% respectively) did not differ after adjustment. Conclusion: After adjusting for contributing variables maternal HTN is not associated with improved survival free of morbidity among ELGANs. Trials Registration: clinicaltrials.gov
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U2 - 10.1038/s41372-023-01631-6
DO - 10.1038/s41372-023-01631-6
M3 - Article
C2 - 36813902
AN - SCOPUS:85148534763
SN - 0743-8346
VL - 43
SP - 430
EP - 436
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 4
ER -