TY - JOUR
T1 - Maternal cerebral blood flow changes in pregnancy
AU - Zeeman, Gerda G.
AU - Hatab, Mustapha
AU - Twickler, Diane M.
PY - 2003/10
Y1 - 2003/10
N2 - OBJECTIVE: This study was undertaken to determine blood flow changes in the large cerebral arteries during normal pregnancy. STUDY DESIGN: Ten healthy pregnant volunteers underwent velocity-encoded phase contrast magnetic resonance imaging at 4 time intervals: 14 to 16, 28 to 32, and 36 to 38 weeks' gestation, and at 6 to 8 weeks' postpartum. Analysis consisted of serial paired Student t tests, with P < .05 considered significant. RESULTS: By using postpartum values for comparison, cerebral blood flow decreased by 14 to 16 weeks in the middle cerebral artery (P < .001), but was not significantly changed in the posterior cerebral artery. Significant decreases occurred in both the middle (P < .0001) and posterior (P = .002) cerebral arteries in late pregnancy. CONCLUSION: An approximately 20% reduction in large artery cerebral blood flow occurs during normal pregnancy, secondary to changes in velocity, whereas the area of these vessels remains unchanged. These findings may represent generalized vasodilatation of downstream resistance arterioles, assuming constant blood flow at the tissue level.
AB - OBJECTIVE: This study was undertaken to determine blood flow changes in the large cerebral arteries during normal pregnancy. STUDY DESIGN: Ten healthy pregnant volunteers underwent velocity-encoded phase contrast magnetic resonance imaging at 4 time intervals: 14 to 16, 28 to 32, and 36 to 38 weeks' gestation, and at 6 to 8 weeks' postpartum. Analysis consisted of serial paired Student t tests, with P < .05 considered significant. RESULTS: By using postpartum values for comparison, cerebral blood flow decreased by 14 to 16 weeks in the middle cerebral artery (P < .001), but was not significantly changed in the posterior cerebral artery. Significant decreases occurred in both the middle (P < .0001) and posterior (P = .002) cerebral arteries in late pregnancy. CONCLUSION: An approximately 20% reduction in large artery cerebral blood flow occurs during normal pregnancy, secondary to changes in velocity, whereas the area of these vessels remains unchanged. These findings may represent generalized vasodilatation of downstream resistance arterioles, assuming constant blood flow at the tissue level.
KW - Cerebral blood flow
KW - Magnetic resonance imaging
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=0242425766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242425766&partnerID=8YFLogxK
U2 - 10.1067/S0002-9378(03)00820-2
DO - 10.1067/S0002-9378(03)00820-2
M3 - Article
C2 - 14586336
AN - SCOPUS:0242425766
SN - 0002-9378
VL - 189
SP - 968
EP - 972
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 4
ER -