Massive left ventricular thrombosis in pericardial decompression syndrome

Andrew Curiale, Srilakshmi Vallabhaneni, Santo Longo, Jamshid Shirani

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: Pericardial decompression syndrome (PDS) is defined as paradoxical hemodynamic deterioration associated with left, right, or bi-ventricular dilation and systolic dysfunction following pericardiocentesis. It is uncommon yet under-recognized, underreported, and associated with significant morbidity and mortality. Case report: We report a unique case of PDS associated with left ventricular (LV) systolic dysfunction and massive apical thrombosis following surgical removal of 800 ml of pericardial fluid in a 72-year-old man with undiagnosed lung cancer. Treatment with anticoagulation and anti-remodeling medications resulted in complete resolution of the thrombus and recovery of LV function. Conclusions: PDS, although rare, can lead to significant morbidity and mortality. Left ventricular apical thrombosis could result from PDS in the setting of hypercoagulable state. Treatment of the underlying disease may lead to successful resolution of PDS and its complications.

Original languageEnglish (US)
Pages (from-to)1471-1473
Number of pages3
Issue number8
StatePublished - Aug 2021
Externally publishedYes


  • cardiac tamponade
  • left ventricular thrombus
  • occult malignancy
  • pericardial decompression syndrome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Massive left ventricular thrombosis in pericardial decompression syndrome'. Together they form a unique fingerprint.

Cite this