Mapping of the pulmonary surfactant SP5 (SFTP2) Locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas

Stephen Wood; M. Lisa Yaremko; Michael Schertzer; Pond R. Kelemen; John Minna; Carol A. Westbrook

doi:10.1006/geno.1994.1673

Mapping of the pulmonary surfactant SP5 (SFTP2) Locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas

Stephen Wood, M. Lisa Yaremko, Michael Schertzer, Pond R. Kelemen, John Minna, Carol A. Westbrook

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We have identified 4 cosmids at the SFTP2 locus by cDNA hybridization. SFTP2 was mapped using a polymorphic CA repeat and localized to 8p21 by FISH. Allele loss in carcinomas was detected using this PCR marker. Among 11 lung and colon tumors, 6 of 9 informative cases exhibited allelic loss.

Original language	English (US)
Pages (from-to)	597-600
Number of pages	4
Journal	Genomics
Volume	24
Issue number	3
DOIs	https://doi.org/10.1006/geno.1994.1673
State	Published - Dec 1994

ASJC Scopus subject areas

Genetics

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title = "Mapping of the pulmonary surfactant SP5 (SFTP2) Locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas",

abstract = "We have identified 4 cosmids at the SFTP2 locus by cDNA hybridization. SFTP2 was mapped using a polymorphic CA repeat and localized to 8p21 by FISH. Allele loss in carcinomas was detected using this PCR marker. Among 11 lung and colon tumors, 6 of 9 informative cases exhibited allelic loss.",

author = "Stephen Wood and Yaremko, {M. Lisa} and Michael Schertzer and Kelemen, {Pond R.} and John Minna and Westbrook, {Carol A.}",

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AU - Yaremko, M. Lisa

AU - Schertzer, Michael

AU - Kelemen, Pond R.

AU - Minna, John

AU - Westbrook, Carol A.

PY - 1994/12

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AB - We have identified 4 cosmids at the SFTP2 locus by cDNA hybridization. SFTP2 was mapped using a polymorphic CA repeat and localized to 8p21 by FISH. Allele loss in carcinomas was detected using this PCR marker. Among 11 lung and colon tumors, 6 of 9 informative cases exhibited allelic loss.

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Mapping of the pulmonary surfactant SP5 (SFTP2) Locus to 8p21 and characterization of a microsatellite repeat marker that shows frequent loss of heterozygosity in human carcinomas

Abstract

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