Manipulation of host membranes by bacterial effectors

Hyeilin Ham, Anju Sreelatha, Kim Orth

Research output: Contribution to journalReview articlepeer-review

107 Scopus citations


Bacterial pathogens interact with host membranes to trigger a wide range of cellular processes during the course of infection. These processes include alterations to the dynamics between the plasma membrane and the actin cytoskeleton, and subversion of the membrane-associated pathways involved in vesicle trafficking. Such changes facilitate the entry and replication of the pathogen, and prevent its phagocytosis and degradation. In this Review, we describe the manipulation of host membranes by numerous bacterial effectors that target phosphoinositide metabolism, GTPase signalling and autophagy.

Original languageEnglish (US)
Pages (from-to)635-646
Number of pages12
JournalNature Reviews Microbiology
Issue number9
StatePublished - Sep 2011

ASJC Scopus subject areas

  • Microbiology
  • General Immunology and Microbiology
  • Infectious Diseases


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