Management of persistent angina after myocardial infarction treated with percutaneous coronary intervention: Insights from the TRANSLATE-ACS study

Alexander C. Fanaroff, Lisa A. Kaltenbach, Eric D. Peterson, Connie N. Hess, David J. Cohen, Gregg C. Fonarow, Tracy Y. Wang

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background--Angina has important implications for patients' quality of life and healthcare utilization. Angina management after acute myocardial infarction (MI) treated with percutaneous coronary intervention (PCI) is unknown. Methods and Results--TRANSLATE-ACS (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) was a longitudinal study of MI patients treated with percutaneous coronary intervention at 233 US hospitals from 2010 to 2012. Among patients with self-reported angina at 6 weeks post-MI, we described patterns of angina and antianginal medication use through 1 year postdischarge. Of 10 870 percutaneous coronary intervention-treated MI patients, 3190 (29.3%) reported angina symptoms at 6 weeks post-MI; of these, 658 (20.6%) had daily/weekly angina while 2532 (79.4%) had monthly angina. Among patients with 6-week angina, 2936 (92.0%) received β-blockers during the 1 year post-MI, yet only 743 (23.3%) were treated with other antianginal medications. At 1 year, 1056 patients (33.1%) with 6-week angina reported persistent angina symptoms. Of these, only 31.2% had been prescribed non-β-blocker antianginal medications at any time in the past year. Among patients undergoing revascularization during follow-up, only 25.9% were on ≥1 non-β-blocker anti-anginal medication at the time of the procedure. Conclusions--Angina is present in one third of percutaneous coronary intervention-treated MI patients as early as 6 weeks after discharge, and many of these patients have persistent angina at 1 year. Non-β-blocker antianginal medications are infrequently used in these patients, even among those with persistent angina and those undergoing revascularization.

Original languageEnglish (US)
Article numbere007007
Pages (from-to)1
Number of pages1
JournalJournal of the American Heart Association
Issue number10
StatePublished - Oct 1 2017
Externally publishedYes


  • Angina pectoris
  • Guideline adherence
  • Myocardial infarction
  • Patient reported outcome
  • Percutaneous coronary intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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