Management of low-grade glioma

Nader Pouratian, David Schiff

Research output: Contribution to journalReview articlepeer-review

110 Scopus citations


The optimal management of patients with lowgrade glioma (LGG) is controversial. The controversy largely stems from the lack of well-designed clinical trials with adequate follow-up to account for the relatively long progression-free survival and overall survival of patients with LGG. Nonetheless, the literature increasingly suggests that expectant management is no longer optimal. Rather, there is mounting evidence supporting active management including consideration of surgical resection, radiotherapy, chemotherapy, molecular and histopathologic characterization, and use of modern imaging techniques for monitoring and prognostication. In particular, there is growing evidence favoring extensive surgical resection and increasing interest in the role of chemotherapy (especially temozolomide) in the management of these tumors. In this review, we critically analyze emerging trends in the literature with respect to management of LGG, with particular emphasis on reports published during the past year.

Original languageEnglish (US)
Pages (from-to)224-231
Number of pages8
JournalCurrent neurology and neuroscience reports
Issue number3
StatePublished - May 2010
Externally publishedYes


  • Astrocytoma
  • Chemotherapy
  • IDH
  • Low-grade glioma
  • Mixed glioma
  • Molecular cytogenetics
  • Oligoastrocytoma
  • Oligodendroglioma
  • Radiation therapy
  • Temozolomide

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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