Male-meadiated behavioral abnormalities

Mary C. Lowery, William W. Au, Perrie M. Adams, Elbert B. Whorton, Marvin S. Legator

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The assessment of behaviral development in the progeny of males exposed to known mutagenic chemicals is a potentially sensitive endpoint for detecting transmissible abonormalities. A genetic components is demonstrated as these behavioral abnormalities can also be passed on to the F2 generation. In this review, experimental studies exploring transmission of behavioral deficits from paternal exposure to drugs, chemicals and radiation are addressed. Additionally included is a brief synopis of recent work perfomed in our laboratory investigating such abnormalities in offspring from male rats exposed to ionizing radiations. The implications of these behavioral endpoints to humans is also discussed.

Original languageEnglish (US)
Pages (from-to)213-229
Number of pages17
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Issue number2
StatePublished - Apr 1990


  • Behaviortal abnormalities
  • Developmental deficits
  • Ionizing radiation
  • Male-mediated effects

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis


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