Male Hypogonadism in Systemic Disease

Rita R. Kalyani, Sravanya Gavini, Adrian S. Dobs

Research output: Contribution to journalReview articlepeer-review

114 Scopus citations


Hypogonadism is often observed in the presence of common acute and chronic illnesses in men. Low testosterone levels in these patients can be associated with loss of lean body mass and bone mass density, decline in mood, loss of energy, and sexual dysfunction. The mechanisms explaining hypogonadism and various systemic diseases are not completely understood, but these conditions are likely caused by a combination of stress, nonspecific weight loss, inflammation, and medication. Testosterone replacement can be considered in this population to improve lean body mass, bone mass density, and quality of life. More information is needed regarding the risk benefits of testosterone treatment on health outcomes in men who have systemic illness.

Original languageEnglish (US)
Pages (from-to)333-348
Number of pages16
JournalEndocrinology and Metabolism Clinics of North America
Issue number2
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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