Abstract
The view of organelles and how they operate together has changed dramatically over the last two decades. The textbook view of organelles was that they operated largely independently and were connected by vesicular trafficking and the diffusion of signals through the cytoplasm. We now know that all organelles make functional close contacts with one another, often called membrane contact sites. The study of these sites has moved to center stage in cell biology as it has become clear that they play critical roles in healthy and developing cells and during cell stress and disease states. Contact sites have important roles in intracellular signaling, lipid metabolism, motor-protein-mediated membrane dynamics, organelle division, and organelle biogenesis. Here, we summarize the major conceptual changes that have occurred in cell biology as we have come to appreciate how contact sites integrate the activities of organelles.
Original language | English (US) |
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Pages (from-to) | 257-270 |
Number of pages | 14 |
Journal | Cell |
Volume | 187 |
Issue number | 2 |
DOIs | |
State | Published - Jan 18 2024 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology