TY - JOUR
T1 - Maintenance of the adult Drosophila intestine
T2 - all roads lead to homeostasis
AU - Guo, Zheng
AU - Lucchetta, Elena
AU - Rafel, Neus
AU - Ohlstein, Benjamin
N1 - Funding Information:
Supported by NIH Grant R01 DK082456-05 and ACS Grant CSM-12499 to Benjamin Ohlstein.
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Maintenance of tissue homeostasis is critical in tissues with high turnover such as the intestinal epithelium. The intestinal epithelium is under constant cellular assault due to its digestive functions and its function as a barrier to chemical and bacterial insults. The resulting high rate of cellular turnover necessitates highly controlled mechanisms of regeneration to maintain the integrity of the tissue over the lifetime of the organism. Transient increase in stem cell proliferation is a commonly used and elaborate mechanism to ensure fast and efficient repair of the gut. However, tissue repair is not limited to regulating ISC proliferation, as emerging evidence demonstrates that the Drosophila intestine uses multiple strategies to ensure proper tissue homeostasis that may also extend to other tissues.
AB - Maintenance of tissue homeostasis is critical in tissues with high turnover such as the intestinal epithelium. The intestinal epithelium is under constant cellular assault due to its digestive functions and its function as a barrier to chemical and bacterial insults. The resulting high rate of cellular turnover necessitates highly controlled mechanisms of regeneration to maintain the integrity of the tissue over the lifetime of the organism. Transient increase in stem cell proliferation is a commonly used and elaborate mechanism to ensure fast and efficient repair of the gut. However, tissue repair is not limited to regulating ISC proliferation, as emerging evidence demonstrates that the Drosophila intestine uses multiple strategies to ensure proper tissue homeostasis that may also extend to other tissues.
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U2 - 10.1016/j.gde.2016.06.009
DO - 10.1016/j.gde.2016.06.009
M3 - Review article
C2 - 27392294
AN - SCOPUS:84978141523
SN - 0959-437X
VL - 40
SP - 81
EP - 86
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -