Macrophages induce differentiation of plasma cells through CXCL10/IP-10

Wei Xu, HyeMee Joo, Sandra Clayton, Melissa Dullaers, Marie Cecile Herve, Derek Blankenship, Maria Teresa De La Morena, Robert Balderas, Capucine Picard, Jean Laurent Casanova, Virginia Pascual, SangKon Oh, Jacques Banchereau

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


In tonsils, CD138+ plasma cells (PCs) are surrounded by CD163+ resident macrophages (Mφs). We show here that human Mφs (isolated from tonsils or generated from monocytes in vitro) drive activated B cells to differentiate into CD138+CD38++ PCs through secreted CXCL10/IP-10 and VCAM-1 contact. IP-10 production by Mφs is induced by B cell-derived IL-6 and depends on STAT3 phosphorylation. Furthermore, IP-10 amplifies the production of IL-6 by B cells, which sustains the STAT3 signals that lead to PC differentiation. IP-10- deficient mice challenged with NP-Ficoll show a decreased frequency of NP-specific PCs and lower titers of antibodies. Thus, our results reveal a novel dialog between Mφs and B cells, in which IP-10 acts as a PC differentiation factor.

Original languageEnglish (US)
Pages (from-to)1813-1823
Number of pages11
JournalJournal of Experimental Medicine
Issue number10
StatePublished - Sep 2012

ASJC Scopus subject areas

  • General Medicine


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