Luminescent gold nanoparticles with efficient renal clearance

Chen Zhou; Michael Long; Yanping Qin; Xiankai Sun; Jie Zheng

doi:10.1002/anie.201007321

Luminescent gold nanoparticles with efficient renal clearance

Chen Zhou, Michael Long, Yanping Qin, Xiankai Sun, Jie Zheng

Research output: Contribution to journal › Article › peer-review

376 Scopus citations

Abstract

Going to waste: Renal clearance of 2-nm glutathione-coated luminescent gold nanoparticles (GS-AuNPs) was more than 10 to 100 times better than that of the similarly sized nonluminescent AuNPs coated by bis(p-sulfonatophenyl) phenylphosphine and cysteine. Urinary excretion of the particles was imaged with X-ray computed tomography (see picture of a mouse after injection of GS-AuNPs) and luminescence techniques in real time.

Original language	English (US)
Pages (from-to)	3168-3172
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	14
DOIs	https://doi.org/10.1002/anie.201007321
State	Published - Mar 28 2011

Keywords

glutathione
gold
luminescence
nanoparticles
renal clearance

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201007321

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AU - Zhou, Chen

AU - Long, Michael

AU - Qin, Yanping

AU - Sun, Xiankai

AU - Zheng, Jie

PY - 2011/3/28

Y1 - 2011/3/28

N2 - Going to waste: Renal clearance of 2-nm glutathione-coated luminescent gold nanoparticles (GS-AuNPs) was more than 10 to 100 times better than that of the similarly sized nonluminescent AuNPs coated by bis(p-sulfonatophenyl) phenylphosphine and cysteine. Urinary excretion of the particles was imaged with X-ray computed tomography (see picture of a mouse after injection of GS-AuNPs) and luminescence techniques in real time.

AB - Going to waste: Renal clearance of 2-nm glutathione-coated luminescent gold nanoparticles (GS-AuNPs) was more than 10 to 100 times better than that of the similarly sized nonluminescent AuNPs coated by bis(p-sulfonatophenyl) phenylphosphine and cysteine. Urinary excretion of the particles was imaged with X-ray computed tomography (see picture of a mouse after injection of GS-AuNPs) and luminescence techniques in real time.

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KW - gold

KW - luminescence

KW - nanoparticles

KW - renal clearance

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Luminescent gold nanoparticles with efficient renal clearance

Abstract

Keywords

ASJC Scopus subject areas

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