Abstract
Examining predictors of blood-pressure (BP) response to weight-loss diets might provide insight into mechanisms and help guide clinical care. We examined whether certain baseline patient characteristics (e.g. diet, medical history and laboratory tests) predicted BP response to two weight-loss diet approaches that differ in macronutrient content. One hundred and forty-six overweight adult outpatients were randomized to either a low-carbohydrate diet (N = 72) or orlistat plus a low-fat diet (N = 74) for 48 weeks. Predictors of BP reduction were evaluated using a structured approach and random effects regression models. Participants were 56% African-American, 72% male and 53 (±10) years-old. Of the variables considered, low baseline high-density lipoprotein (HDL) predicted greater reduction in BP in those patients who received the low-carbohydrate diet (p = 0.03 for systolic BP; p = 0.03 for diastolic BP and p = 0.02 for mean arterial pressure). A low HDL level may identify patients who will have greater BP improvement on a low-carbohydrate diet. Published 2011. This article is a U.S. Government work and is in the public domain in the USA.
Original language | English (US) |
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Pages (from-to) | 375-378 |
Number of pages | 4 |
Journal | Diabetes, Obesity and Metabolism |
Volume | 14 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2012 |
Keywords
- Clinical trial
- Dietary intervention
- Dyslipidaemia
- Hypertension
- Obesity therapy
- Weight-loss therapy
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Endocrinology