Low-Dose Insulin: A Plea for Caution

L. L. Madison

Research output: Contribution to journalEditorialpeer-review

37 Scopus citations


Three recent reports123promulgating continuous intravenous infusions of low-dose insulin (1.2 to 12.0 U per hour, with or without an initial priming dose of 0.5 to 12 U) as a safe, simple and effective method of treating diabetic ketoacidosis, coupled with favorable editorial reviews45have resulted in premature acceptance and widespread use of this new regimen. Before these reports many centers had abandoned subcutaneous and intramuscular insulin in the early treatment of diabetic ketoacidosis.67891011The variable rate of absorption from these sites in a disorder uniformly characterized by extracellular-fluid depletion and even overt shock increases the possibility that large depots.

Original languageEnglish (US)
Pages (from-to)393-394
Number of pages2
JournalNew England Journal of Medicine
Issue number7
StatePublished - Feb 12 1976

ASJC Scopus subject areas

  • Medicine(all)


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