Loss of T cells influences sex differences in stress-related gene expression

Kelly C. Rilett, Owen D. Luo, Karen Anne McVey-Neufeld, Robyn N. MacKenzie, Jane A. Foster

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Deficiencies in the adaptive immune system have been linked to anxiety-like behaviours and stress reactivity. Mice lacking T lymphocytes through knockout of the T cell receptor (TCR) β and δ chains were compared to wild type C57Bl/6 mice. Central stress circuitry gene expression was assessed following repeated restraint stress. TCRβ−/−δ−/− mice showed an increased baseline plasma corticosterone and exaggerated changes in stress-related gene expression after repeated restraint stress. Sexual dimorphic stress responses were observed in wild-type C57Bl/6 mice but not in TCRβ−/−δ−/− mice. These data suggest that T cell-brain interactions influence sex-differences in CNS stress circuitry and stress reactivity.

Original languageEnglish (US)
Article number577213
JournalJournal of Neuroimmunology
StatePublished - Jun 15 2020
Externally publishedYes


  • Immune-brain
  • Sex difference
  • Stress reactivity
  • T lymphocyte

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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