Abstract
Deficiencies in the adaptive immune system have been linked to anxiety-like behaviours and stress reactivity. Mice lacking T lymphocytes through knockout of the T cell receptor (TCR) β and δ chains were compared to wild type C57Bl/6 mice. Central stress circuitry gene expression was assessed following repeated restraint stress. TCRβ−/−δ−/− mice showed an increased baseline plasma corticosterone and exaggerated changes in stress-related gene expression after repeated restraint stress. Sexual dimorphic stress responses were observed in wild-type C57Bl/6 mice but not in TCRβ−/−δ−/− mice. These data suggest that T cell-brain interactions influence sex-differences in CNS stress circuitry and stress reactivity.
Original language | English (US) |
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Article number | 577213 |
Journal | Journal of Neuroimmunology |
Volume | 343 |
DOIs | |
State | Published - Jun 15 2020 |
Externally published | Yes |
Keywords
- Immune-brain
- Sex difference
- Stress reactivity
- T lymphocyte
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology