Loss of class I MHC function alters behavior and stress reactivity

Ashwin Sankar; Robyn N. MacKenzie; Jane A. Foster

doi:10.1016/j.jneuroim.2011.12.025

Loss of class I MHC function alters behavior and stress reactivity

Ashwin Sankar, Robyn N. MacKenzie, Jane A. Foster

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The importance of the classical immune molecule, class I major histocompatibility complex to central nervous system function is one of the most surprising discoveries related to neuroimmunology in the past decade. Mice lacking both β-2microglobulin and transporter associated with antigen processing (β2M-/-TAP-/-) showed differences in basal behavior. In response to saline injection, β2M-/-TAP-/- mice showed a significant hypothalamic pituitary adrenal activation that was not observed in wild type mice, while lipopolysaccharide-induced cytokine expression in the hypothalamus was similar in β2M-/-TAP-/- and wild type mice. Overall, these data show that class I MHC plays an important role in behavior and stress reactivity.

Original language	English (US)
Pages (from-to)	8-15
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	244
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2011.12.025
State	Published - Mar 2012
Externally published	Yes

Keywords

Cytokines
Elevated plus maze
Lipopolysaccharide
Open field
Sickness behavior
Stress response

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2011.12.025

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title = "Loss of class I MHC function alters behavior and stress reactivity",

abstract = "The importance of the classical immune molecule, class I major histocompatibility complex to central nervous system function is one of the most surprising discoveries related to neuroimmunology in the past decade. Mice lacking both β-2microglobulin and transporter associated with antigen processing (β2M-/-TAP-/-) showed differences in basal behavior. In response to saline injection, β2M-/-TAP-/- mice showed a significant hypothalamic pituitary adrenal activation that was not observed in wild type mice, while lipopolysaccharide-induced cytokine expression in the hypothalamus was similar in β2M-/-TAP-/- and wild type mice. Overall, these data show that class I MHC plays an important role in behavior and stress reactivity.",

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AU - MacKenzie, Robyn N.

AU - Foster, Jane A.

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KW - Open field

KW - Sickness behavior

KW - Stress response

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Loss of class I MHC function alters behavior and stress reactivity

Abstract

Keywords

ASJC Scopus subject areas

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