Loss of class I MHC function alters behavior and stress reactivity

Ashwin Sankar, Robyn N. MacKenzie, Jane A. Foster

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The importance of the classical immune molecule, class I major histocompatibility complex to central nervous system function is one of the most surprising discoveries related to neuroimmunology in the past decade. Mice lacking both β-2microglobulin and transporter associated with antigen processing (β2M-/-TAP-/-) showed differences in basal behavior. In response to saline injection, β2M-/-TAP-/- mice showed a significant hypothalamic pituitary adrenal activation that was not observed in wild type mice, while lipopolysaccharide-induced cytokine expression in the hypothalamus was similar in β2M-/-TAP-/- and wild type mice. Overall, these data show that class I MHC plays an important role in behavior and stress reactivity.

Original languageEnglish (US)
Pages (from-to)8-15
Number of pages8
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - Mar 2012
Externally publishedYes


  • Cytokines
  • Elevated plus maze
  • Lipopolysaccharide
  • Open field
  • Sickness behavior
  • Stress response

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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