Loracarbef concentrations in middle ear fluid

H. Kusmiesz; S. Shelton; O. Brown; S. Manning; J. D. Nelson

doi:10.1128/AAC.34.10.2030

Loracarbef concentrations in middle ear fluid

H. Kusmiesz, S. Shelton, O. Brown, S. Manning, J. D. Nelson

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Abstract

Loracarbef concentrations in plasma and middle ear fluid (MEF) were measured in specimens obtained approximately 2 h after doses of 7.5 or 15 mg/kg. The mean ± standard deviation concentrations in MEF were 2.0 ± 2.6 mg/liter (48% of the concentration in plasma) after the smaller dose and 3.9 ± 2.6 mg/liter (42% of the concentration in plasma) after the larger dose. With the larger dose, the concentrations in MEF were greater than the MIC for 90% of strains of the usual pathogens of acute otitis media tested in 16 of 17 specimens.

Original language	English (US)
Pages (from-to)	2030-2031
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	34
Issue number	10
DOIs	https://doi.org/10.1128/AAC.34.10.2030
State	Published - 1990

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Loracarbef concentrations in plasma and middle ear fluid (MEF) were measured in specimens obtained approximately 2 h after doses of 7.5 or 15 mg/kg. The mean ± standard deviation concentrations in MEF were 2.0 ± 2.6 mg/liter (48% of the concentration in plasma) after the smaller dose and 3.9 ± 2.6 mg/liter (42% of the concentration in plasma) after the larger dose. With the larger dose, the concentrations in MEF were greater than the MIC for 90% of strains of the usual pathogens of acute otitis media tested in 16 of 17 specimens.",

author = "H. Kusmiesz and S. Shelton and O. Brown and S. Manning and Nelson, {J. D.}",

year = "1990",

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AU - Kusmiesz, H.

AU - Shelton, S.

AU - Brown, O.

AU - Manning, S.

AU - Nelson, J. D.

PY - 1990

Y1 - 1990

N2 - Loracarbef concentrations in plasma and middle ear fluid (MEF) were measured in specimens obtained approximately 2 h after doses of 7.5 or 15 mg/kg. The mean ± standard deviation concentrations in MEF were 2.0 ± 2.6 mg/liter (48% of the concentration in plasma) after the smaller dose and 3.9 ± 2.6 mg/liter (42% of the concentration in plasma) after the larger dose. With the larger dose, the concentrations in MEF were greater than the MIC for 90% of strains of the usual pathogens of acute otitis media tested in 16 of 17 specimens.

AB - Loracarbef concentrations in plasma and middle ear fluid (MEF) were measured in specimens obtained approximately 2 h after doses of 7.5 or 15 mg/kg. The mean ± standard deviation concentrations in MEF were 2.0 ± 2.6 mg/liter (48% of the concentration in plasma) after the smaller dose and 3.9 ± 2.6 mg/liter (42% of the concentration in plasma) after the larger dose. With the larger dose, the concentrations in MEF were greater than the MIC for 90% of strains of the usual pathogens of acute otitis media tested in 16 of 17 specimens.

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Loracarbef concentrations in middle ear fluid

Abstract

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