Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete

Katherine N. Maloney, John B. MacMillan, Christopher A. Kauffman, Paul R. Jensen, Antonio G. Dipasquale, Arnold L. Rheingold, William Fenical

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


"Chemical Equation Presented" Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC 50 = 3.6 μM.

Original languageEnglish (US)
Pages (from-to)5422-5424
Number of pages3
JournalOrganic Letters
Issue number23
StatePublished - Dec 3 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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