Local harmonic motion for in vivo focused ultrasound surgery monitoring

Laura Curiel, Rajiv Chopra, Kullervo Hynynen

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The present study established the feasibility of a technique for monitoring FTJS lesion formation in vivo using localized harmonic motion (LHM) measurements. Oscillatory motion was generated within tissues by induction of a periodic radiation force with a focused ultrasound (FTJS) transducer. The harmonic motion was estimated using cross-correlation of RF ultrasonic signals acquired at different instances during the motion by using a co-focal diagnostic ultrasound transducer. The technique was evaluated in vivo rabbit muscle in an MR imager for simultaneous ultrasound harmonic motion tracking and MR thermometry. The calculated maximum amplitude of the induced harmonic motion before and after the lesion formation was significantly different for all the tested motion frequencies. During the FUS exposure a drop in the maximum amplitude value was observed and a threshold value could be associated to the formation of a thermal lesion. A series of controlled sonications was performed by stopping the exposure when the threshold value in LHM amplitude was reached and the apparition of a thermal lesion was confirmed by MR imaging.

Original languageEnglish (US)
Title of host publication2007 IEEE Ultrasonics Symposium Proceedings, IUS
Number of pages4
StatePublished - Dec 1 2007
Event2007 IEEE Ultrasonics Symposium, IUS - New York, NY, United States
Duration: Oct 28 2007Oct 31 2007

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117


Other2007 IEEE Ultrasonics Symposium, IUS
Country/TerritoryUnited States
CityNew York, NY


  • Elastography
  • FUS
  • HIFU
  • Lesion
  • Monitoring
  • Radiation force
  • Tissue ablation
  • Ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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