Liver cancer risk-predictive molecular biomarkers specific to clinico-epidemiological contexts

Naoto Kubota, Naoto Fujiwara, Yujin Hoshida

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Hepatocellular carcinoma (HCC) risk prediction is increasingly important because of the low annual HCC incidence in patients with the rapidly emerging non-alcoholic fatty liver disease or cured HCV infection. To date, numerous clinical HCC risk biomarkers and scores have been reported in literature. However, heterogeneity in clinico-epidemiological context, e.g., liver disease etiology, patient race/ethnicity, regional environmental exposure, and lifestyle-related factors, obscure their real clinical utility and applicability. Proper characterization of these factors will help refine HCC risk prediction according to certain clinical context/scenarios and contribute to improved early HCC detection. Molecular factors underlying the clinical heterogeneity encompass various features in host genetics, hepatic and systemic molecular dysregulations, and cross-organ interactions, which may serve as clinical-context-specific biomarkers and/or therapeutic targets. Toward the goal to enable individual-risk-based HCC screening by incorporating the HCC risk biomarkers/scores, their assessment in patient with well-defined clinical context/scenario is critical to gauge their real value and to maximize benefit of the tailored patient management for substantial improvement of the poor HCC prognosis.

Original languageEnglish (US)
Title of host publicationHepatobiliary Cancers
Subtitle of host publicationTranslational Advances and Molecular Medicine
EditorsAlphonse E. Sirica, Alphonse E. Sirica, Paul B. Fisher
PublisherAcademic Press Inc.
Number of pages37
ISBN (Print)9780323983921
StatePublished - Jan 2022
Externally publishedYes

Publication series

NameAdvances in Cancer Research
ISSN (Print)0065-230X
ISSN (Electronic)2162-5557


  • Cancer screening
  • Cirrhosis
  • Clinical risk score
  • Hepatocellular carcinoma
  • Molecular risk score
  • Precision medicine
  • Risk prediction

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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