Light-induced degradation of TIMELESS and entrainment of the drosophila circadian clock

Michael P. Myers, Karen Wager-Smith, Adrian Rothenfluh-Hilfiker, Michael W. Young

Research output: Contribution to journalArticlepeer-review

420 Scopus citations


Two genes, period (per) and timeless (tim), are required for production of circadian rhythms in Drosophila. The proteins encoded by these genes (PER and TIM) physically interact, and the timing of their association and nuclear localization is believed to promote cycles of per and tim transcription through an autoregulatory feedback loop. Here it is shown that TIM protein may also couple this molecular pacemaker to the environment, because TIM is rapidly degraded after exposure to light. Tim accumulated rhythmically in nuclei of eyes and pacemaker cells of the brain. The phase of these rhythms was differently advanced or delayed by light pulses delivered at different times of the day, corresponding with phase shifts induced in the behavioral rhythms.

Original languageEnglish (US)
Pages (from-to)1736-1740
Number of pages5
Issue number5256
StatePublished - Mar 22 1996

ASJC Scopus subject areas

  • General


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