Lewy-body formation is an aggresome-related process: A hypothesis

C. Warren Olanow, Daniel P. Perl, George N. DeMartino, Kevin St P McNaught

Research output: Contribution to journalComment/debatepeer-review

254 Scopus citations


Parkinson's disease (PD) is an age-related neurodegenerative disorder that is associated with the formation of intracytoplasmic protein aggregates (Lewy-body inclusions) in neurons of the substantia nigra pars compacta and other brain areas. These inclusions were discovered over 90 years ago, but the mechanism underlying their formation and their relevance to the neurodegenerative process are unknown. Recent studies have begun to shed light on the biogenesis of Lewy bodies and suggest that they are related to aggresomes. Aggresomes are cytoprotective proteinaceous inclusions formed at the centrosome that segregate and facilitate the degradation of excess amounts of unwanted and possibly cytotoxic proteins. The concept of Lewy bodies as aggresome-related inclusions fits well with ongoing discoveries suggesting that altered protein handling might contribute to the neurodegenerative process in familial and sporadic forms of PD.

Original languageEnglish (US)
Pages (from-to)496-503
Number of pages8
JournalLancet Neurology
Issue number8
StatePublished - Aug 1 2004

ASJC Scopus subject areas

  • Clinical Neurology


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