Leucine-rich repeat kinase 2 for beginners: Six key questions

Lauren R. Kett, William T. Dauer

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


There has been intense interest in leucine-rich repeat kinase 2 (LRRK2) since 2004, when mutations in the LRRK2 gene were discovered to cause dominantly inherited Parkinson's disease (PD). This article will address six basic questions about LRRK2 biology as it relates to PD, with particular emphasis on its discovery, current concepts of its physiological and pathological functions, and the strategies being used to discover how LRRK2 dysfunction causes PD.

Original languageEnglish (US)
JournalCold Spring Harbor Perspectives in Medicine
Issue number3
StatePublished - Mar 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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