Leucine-rich repeat kinase 2 for beginners: Six key questions

Lauren R. Kett; William T. Dauer

doi:10.1101/cshperspect.a009407

Leucine-rich repeat kinase 2 for beginners: Six key questions

Lauren R. Kett, William T. Dauer

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

There has been intense interest in leucine-rich repeat kinase 2 (LRRK2) since 2004, when mutations in the LRRK2 gene were discovered to cause dominantly inherited Parkinson's disease (PD). This article will address six basic questions about LRRK2 biology as it relates to PD, with particular emphasis on its discovery, current concepts of its physiological and pathological functions, and the strategies being used to discover how LRRK2 dysfunction causes PD.

Original language	English (US)
Journal	Cold Spring Harbor Perspectives in Medicine
Volume	2
Issue number	3
DOIs	https://doi.org/10.1101/cshperspect.a009407
State	Published - Mar 2012
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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abstract = "There has been intense interest in leucine-rich repeat kinase 2 (LRRK2) since 2004, when mutations in the LRRK2 gene were discovered to cause dominantly inherited Parkinson's disease (PD). This article will address six basic questions about LRRK2 biology as it relates to PD, with particular emphasis on its discovery, current concepts of its physiological and pathological functions, and the strategies being used to discover how LRRK2 dysfunction causes PD.",

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Leucine-rich repeat kinase 2 for beginners: Six key questions

Abstract

ASJC Scopus subject areas

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