Lessons in hypertension from new clinical trials

Research output: Contribution to journalArticlepeer-review


Three important principles have emerged from recent epidemiologic and clinical studies in hypertension. First, patients with hypertension most often have other cardiovascular risk factors such as obesity and diabetes. Second, hypertension remains grossly undertreated. Third, at blood pressure levels once considered "high-normal," early organ damage may already be taking place in patients with multiple risk factors that, without treatment, can eventually lead to cardiovascular morbidity and mortality. The concept of evaluating global or overall risk is gaining wide acceptance, and US treatment guidelines may soon reflect these findings and assist clinicians in identifying individuals who are most likely to benefit from therapy. Results from clinical trials suggest that among the various pharmacologic agents available to treat hypertension, blockers of the renin-angiotensin system are effective in type 2 diabetes and chronic kidney disease, conditions that often occur in conjunction with hypertension.

Original languageEnglish (US)
Pages (from-to)34-43
Number of pages10
JournalPostgraduate medicine
Issue number6
StatePublished - Nov 1 2009


  • Angiotensin receptor blockers
  • Cardiovascular disease
  • Hypertension
  • Reninangiotensin system
  • Treatment guidelines

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Lessons in hypertension from new clinical trials'. Together they form a unique fingerprint.

Cite this