Previously reported studies identified analogues of propafenone that had potent antimalarial activity, reduced cardiac ion channel activity, and properties that suggested the potential for clinical development for malaria. Careful examination of the bioavailability, pharmacokinetics, toxicology, and efficacy of this series of compounds using rodent models revealed orally bioavailable compounds that are nontoxic and suppress parasitemia in vivo. Although these compounds possess potential for further preclinical development, they also carry some significant challenges.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Medicinal Chemistry|
|State||Published - Jul 12 2012|
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery