TY - JOUR
T1 - Latex carrier for improving protoporphyrin IX for photodynamic therapy
AU - Bui, Brian
AU - Liu, Li
AU - Chen, Wei
N1 - Funding Information:
We would like to acknowledge the support from the U.S. Army Medical Research Acquisition Activity (USAMRAA) under Contracts of W81XWH-10-1-0279 and W81XWH-10-1-0234 and the NSF and DHS joint ARI program (2008-DN-077-ARI016-05, CBET-1039068).
Publisher Copyright:
© 2016 Elsevier B.V.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Attachment of Protoporphyrin IX (PPIX) to poly (styrene-co-4-vinylpyridine) (PS4VP) nanobeads was carried out to improve its properties in aqueous solutions. After using an oil-in-water heated emulsion polymerization technique to synthesize PS4VP, PPIX was bonded to the particles via the carboxylic acid of PPIX hydrogen-bonding to the nitrogen at the surface of PS4VP, thereby preventing self-reactions between the carboxyl groups and the porphyrin core. Refraining the two parts from interacting while attached to the nanobeads prevented PPIX from aggregating, which then increased water solubility, enhanced luminescence and singlet oxygen production. Attachment also improved cell uptake and cell destruction by photodynamic activity. This shows that PS4VP-PPIX may help improve aspects of photodynamic therapy for the treatment of cancer.
AB - Attachment of Protoporphyrin IX (PPIX) to poly (styrene-co-4-vinylpyridine) (PS4VP) nanobeads was carried out to improve its properties in aqueous solutions. After using an oil-in-water heated emulsion polymerization technique to synthesize PS4VP, PPIX was bonded to the particles via the carboxylic acid of PPIX hydrogen-bonding to the nitrogen at the surface of PS4VP, thereby preventing self-reactions between the carboxyl groups and the porphyrin core. Refraining the two parts from interacting while attached to the nanobeads prevented PPIX from aggregating, which then increased water solubility, enhanced luminescence and singlet oxygen production. Attachment also improved cell uptake and cell destruction by photodynamic activity. This shows that PS4VP-PPIX may help improve aspects of photodynamic therapy for the treatment of cancer.
KW - Latex carrier
KW - Photodynamic therapy (PDT)
KW - Protoporphyrin (PPIX)
UR - http://www.scopus.com/inward/record.url?scp=84964430260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964430260&partnerID=8YFLogxK
U2 - 10.1016/j.pdpdt.2016.03.007
DO - 10.1016/j.pdpdt.2016.03.007
M3 - Article
C2 - 27020668
AN - SCOPUS:84964430260
SN - 1572-1000
VL - 14
SP - 159
EP - 165
JO - Photodiagnosis and Photodynamic Therapy
JF - Photodiagnosis and Photodynamic Therapy
ER -