Laser interstitial thermal therapy for treatment of post-radiosurgery tumor recurrence and radiation necrosis

Toral R. Patel, Veronica L S Chiang

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Background and objective: Approximately one-third of all intracranial metastatic lesions treated with stereotactic radiosurgery (SRS) will regrow at some point during follow-up. A fraction of these lesions will require further therapy. Traditional approaches will work in a majority of, but not all, cases. Laser interstitial thermal therapy (LITT) represents a promising strategy for treatment of regrowing lesions post-SRS that are refractory to standard therapies. Materials and methods: Published literature to evaluate the role of LITT for treatment of regrowing metastatic lesions post-SRS is reviewed; own single institution experience treating these pathologies with two different commercially available LITT systems is included. Results: Early clinical studies have established that LITT can be used to successfully treat post-SRS regrowing lesions. Patients treated with LITT demonstrate both clinical and radiographic improvements following treatment, with minimal side effects. Conclusions: LITT is a promising new therapy for the management of post-SRS regrowing intracranial metastases. Large-scale clinical trials demonstrating therapeutic efficacy must be completed prior to widespread adoption of this technique.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalPhotonics and Lasers in Medicine
Issue number2
StatePublished - Apr 2014


  • Brain metastases
  • Laser interstitial thermal therapy
  • Radiation necrosis
  • Stereotactic radiosurgery
  • Tumor regrowth

ASJC Scopus subject areas

  • Surgery
  • Dermatology


Dive into the research topics of 'Laser interstitial thermal therapy for treatment of post-radiosurgery tumor recurrence and radiation necrosis'. Together they form a unique fingerprint.

Cite this