Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current

Heinz Grunze; Robert W. Greene; Hans Jürgen Möller; Thorsten Meyer; Jörg Walden

doi:10.1016/S0006-8993(98)00180-2

Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current

Heinz Grunze, Robert W. Greene, Hans Jürgen Möller, Thorsten Meyer, Jörg Walden

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Actions of the new antiepileptic drug lamotrigine were characterised using whole cell patch clamp recordings from rat CA1 pyramidal cells in vitro. The results suggest that lamotrigine, besides its previously described effect on the fast sodium inward current and calcium currents, modulates the transient potassium outward current I(D). This may be an effective mechanism to inhibit pathological excitation.

Original language	English (US)
Pages (from-to)	330-334
Number of pages	5
Journal	Brain Research
Volume	791
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(98)00180-2
State	Published - Apr 27 1998

Keywords

Bipolar affective disorder
Epilepsy
Hippocampus
Lamotrigine
Potassium current

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(98)00180-2

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abstract = "Actions of the new antiepileptic drug lamotrigine were characterised using whole cell patch clamp recordings from rat CA1 pyramidal cells in vitro. The results suggest that lamotrigine, besides its previously described effect on the fast sodium inward current and calcium currents, modulates the transient potassium outward current I(D). This may be an effective mechanism to inhibit pathological excitation.",

keywords = "Bipolar affective disorder, Epilepsy, Hippocampus, Lamotrigine, Potassium current",

author = "Heinz Grunze and Greene, {Robert W.} and M{\"o}ller, {Hans J{\"u}rgen} and Thorsten Meyer and J{\"o}rg Walden",

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AU - Grunze, Heinz

AU - Greene, Robert W.

AU - Möller, Hans Jürgen

AU - Meyer, Thorsten

AU - Walden, Jörg

PY - 1998/4/27

Y1 - 1998/4/27

N2 - Actions of the new antiepileptic drug lamotrigine were characterised using whole cell patch clamp recordings from rat CA1 pyramidal cells in vitro. The results suggest that lamotrigine, besides its previously described effect on the fast sodium inward current and calcium currents, modulates the transient potassium outward current I(D). This may be an effective mechanism to inhibit pathological excitation.

AB - Actions of the new antiepileptic drug lamotrigine were characterised using whole cell patch clamp recordings from rat CA1 pyramidal cells in vitro. The results suggest that lamotrigine, besides its previously described effect on the fast sodium inward current and calcium currents, modulates the transient potassium outward current I(D). This may be an effective mechanism to inhibit pathological excitation.

KW - Bipolar affective disorder

KW - Epilepsy

KW - Hippocampus

KW - Lamotrigine

KW - Potassium current

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Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current

Abstract

Keywords

ASJC Scopus subject areas

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