TY - JOUR
T1 - L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy
AU - Gibbons, Christopher H.
AU - Vernino, Steven A.
AU - Kaufmann, Horacio
AU - Freeman, Roy
PY - 2005/10/11
Y1 - 2005/10/11
N2 - The authors report a 46-year-old woman with antibodies to the nicotinic acetylcholine receptor (NiAchR) of the autonomic ganglia. She presented with severe orthostatic intolerance refractory to treatment with midodrine, fludrocortisone, erythropoietin, vasopressin, salt, and fluid loading. Addition of L-threo-3,4-dihidroxyphenylserine (L-DOPS) substantially improved blood pressure and orthostatic tolerance. L-DOPS may benefit patients with severe orthostatic intolerance and be particularly effective in patients with ganglionic NiAchR antibodies.
AB - The authors report a 46-year-old woman with antibodies to the nicotinic acetylcholine receptor (NiAchR) of the autonomic ganglia. She presented with severe orthostatic intolerance refractory to treatment with midodrine, fludrocortisone, erythropoietin, vasopressin, salt, and fluid loading. Addition of L-threo-3,4-dihidroxyphenylserine (L-DOPS) substantially improved blood pressure and orthostatic tolerance. L-DOPS may benefit patients with severe orthostatic intolerance and be particularly effective in patients with ganglionic NiAchR antibodies.
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U2 - 10.1212/01.wnl.0000178980.83477.14
DO - 10.1212/01.wnl.0000178980.83477.14
M3 - Article
C2 - 16217067
AN - SCOPUS:26444580752
SN - 0028-3878
VL - 65
SP - 1104
EP - 1106
JO - Neurology
JF - Neurology
IS - 7
ER -