Krebs takes a turn at cell differentiation

Stanisław Deja; Peter A. Crawford; Shawn C. Burgess

doi:10.1016/j.cmet.2022.04.005

Krebs takes a turn at cell differentiation

Stanisław Deja, Peter A. Crawford, Shawn C. Burgess

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.

Original language	English (US)
Pages (from-to)	658-660
Number of pages	3
Journal	Cell Metabolism
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2022.04.005
State	Published - May 3 2022

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2022.04.005

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title = "Krebs takes a turn at cell differentiation",

abstract = "In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.",

author = "Stanis{\l}aw Deja and Crawford, {Peter A.} and Burgess, {Shawn C.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

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day = "3",

doi = "10.1016/j.cmet.2022.04.005",

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T1 - Krebs takes a turn at cell differentiation

AU - Deja, Stanisław

AU - Crawford, Peter A.

AU - Burgess, Shawn C.

PY - 2022/5/3

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N2 - In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.

AB - In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.

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DO - 10.1016/j.cmet.2022.04.005

M3 - Comment/debate

C2 - 35508108

AN - SCOPUS:85129346017

SN - 1550-4131

VL - 34

SP - 658

EP - 660

JO - Cell Metabolism

JF - Cell Metabolism

IS - 5

ER -

Krebs takes a turn at cell differentiation

Abstract

ASJC Scopus subject areas

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