TY - JOUR
T1 - Klotho connects intermedin1-53 to suppression of vascular calcification in chronic kidney disease
AU - Hu, Ming C
N1 - Publisher Copyright:
© 2016 International Society of Nephrology.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Vascular calcification is one of the leading causes of death in chronic kidney disease (CKD) patients. Klotho protein encoded by the anti-aging gene, Klotho, and intermedin1-53 have both been shown to protect the vasculature from calcification in CKD. The study by Chang and colleagues links Klotho and intermedin1-53 in prevention of vascular calcification in CKD by showing that intermedin1-53 increased renal, vascular, and plasma Klotho, and reduced vascular calcification in CKD rats. Intermedin1-53 may be a novel therapeutic agent for CKD.
AB - Vascular calcification is one of the leading causes of death in chronic kidney disease (CKD) patients. Klotho protein encoded by the anti-aging gene, Klotho, and intermedin1-53 have both been shown to protect the vasculature from calcification in CKD. The study by Chang and colleagues links Klotho and intermedin1-53 in prevention of vascular calcification in CKD by showing that intermedin1-53 increased renal, vascular, and plasma Klotho, and reduced vascular calcification in CKD rats. Intermedin1-53 may be a novel therapeutic agent for CKD.
UR - http://www.scopus.com/inward/record.url?scp=84964556814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964556814&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2015.12.036
DO - 10.1016/j.kint.2015.12.036
M3 - Comment/debate
C2 - 26880448
AN - SCOPUS:84964556814
SN - 0085-2538
VL - 89
SP - 534
EP - 537
JO - Kidney international
JF - Kidney international
IS - 3
ER -