Key role of microRNAs in Waldenström's macroglobulinemia pathogenesis

Antonio Sacco, Patricia Maiso, Abdelkareem Azab, Feda Azab, Yong Zhang, Yang Liu, Hai T. Ngo, Brittany Morgan, Phong Quang, Ghayas Issa, Irene M. Ghobrial, Aldo M. Roccaro

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Epigenetics represent heritable changes in gene expression that are not due to any alteration in the DNA sequence. One of the best-known epigenetic markers is histone acetylation, which has been shown to be deregulated in neoplastic diseases, including B-cell malignancies, such as Waldenström's Macroglobulinemia (WM), a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a serum monoclonal immunoglobulin M in the circulation. It has been recently demonstrated that microRNAs may be responsible for modulating histone acetylation in WM cells, thus providing the preclinical evidences for using microRNA-based therapeutic strategies in this disease.

Original languageEnglish (US)
Pages (from-to)109-111
Number of pages3
JournalClinical Lymphoma, Myeloma and Leukemia
Issue number1
StatePublished - Feb 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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