JCL roundtable: Diagnosis and clinical management of lipodystrophy

William Virgil Brown, Abhimanyu Garg, Phillip Gorden, Robert Shamburek

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Lipodystrophy comes in several forms, some involving the complete failure to develop adipose tissue and others with a partial absence in various bodily distributions. All appear to have a major genetic basis, and all involve a high frequency of lipoprotein disorders. High triglycerides and low high-density lipoprotein cholesterol are the usual findings that raise interesting questions as to how such abnormalities characteristic of obesity can be caused by genetic variants that produce a paucity of adiposity. We are learning to link some specific genetic variants that seem causal and to manage these disorders in more effective ways. We are joined by 3 experts who have been leaders in the study of the clinical presentation, genetics, abnormal physiology, and the management of lipodystrophy in recent years. They are Drs Abhimanyu Garg from the University of Texas Southwestern, Phillip Gorden of the National Institute of Diabetes, Digestive and Kidney Diseases, and Robert Shamburek of the National Heart, Lung and Blood Institute.

Original languageEnglish (US)
Pages (from-to)728-736
Number of pages9
JournalJournal of Clinical Lipidology
Issue number4
StatePublished - Jul 1 2016


  • Adipose tissue
  • HDL cholesterol
  • Lipodystrophy
  • Obesity
  • Triglycerides

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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