TY - JOUR
T1 - Itch, eosinophils, and autoimmunity
T2 - A novel murine model of bullous pemphigoid
AU - Yancey, Kim B.
N1 - Publisher Copyright:
© 2015 The Society for Investigative Dermatology.
PY - 2015/5/22
Y1 - 2015/5/22
N2 - Mice carrying a deletion in the NC14A domain of murine type XVII collagen begin scratching at age 2 months and then develop erosions, subepidermal vesicles, eosinophil-rich skin infiltrates, and autoantibodies directed against a 180 kDa skin protein that appears to be type XVII collagen. These mice represent a bullous pemphigoid animal model featuring pruritus in immunocompetent, mature, and largely unmanipulated animals.
AB - Mice carrying a deletion in the NC14A domain of murine type XVII collagen begin scratching at age 2 months and then develop erosions, subepidermal vesicles, eosinophil-rich skin infiltrates, and autoantibodies directed against a 180 kDa skin protein that appears to be type XVII collagen. These mice represent a bullous pemphigoid animal model featuring pruritus in immunocompetent, mature, and largely unmanipulated animals.
UR - http://www.scopus.com/inward/record.url?scp=84928401841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928401841&partnerID=8YFLogxK
U2 - 10.1038/jid.2014.537
DO - 10.1038/jid.2014.537
M3 - Comment/debate
C2 - 25882461
AN - SCOPUS:84928401841
SN - 0022-202X
VL - 135
SP - 1213
EP - 1215
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 5
ER -