Isolation and characterization of the Haemophilus influenzae uvrA gene

Maria L. De La Morena; David R. Hendrixson; Joseph W. St. Geme

doi:10.1016/0378-1119(96)00264-8

Isolation and characterization of the Haemophilus influenzae uvrA gene

Maria L. De La Morena, David R. Hendrixson, Joseph W. St. Geme

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The uvrA gene of Haemophilus influenzae (Hi) was cloned and sequenced. Analysis of the deduced amino acid sequence revealed 81% identity and 90% similarity with the Escherichia coli UvrA protein. Consistent with a role of Hi uvrA in DNA repair, a Hi uvrA mutant exhibited increased sensitivity of UV irradiation. Furthermore, Hi uvr A was able to complement a mutation in the E. coli uvrA locus.

Original language	English (US)
Pages (from-to)	23-28
Number of pages	6
Journal	Gene
Volume	177
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-1119(96)00264-8
State	Published - Oct 24 1996

Keywords

DNA damage
DNA repair
Excinuclease
Nucleotide excision

ASJC Scopus subject areas

Genetics

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10.1016/0378-1119(96)00264-8

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title = "Isolation and characterization of the Haemophilus influenzae uvrA gene",

abstract = "The uvrA gene of Haemophilus influenzae (Hi) was cloned and sequenced. Analysis of the deduced amino acid sequence revealed 81% identity and 90% similarity with the Escherichia coli UvrA protein. Consistent with a role of Hi uvrA in DNA repair, a Hi uvrA mutant exhibited increased sensitivity of UV irradiation. Furthermore, Hi uvr A was able to complement a mutation in the E. coli uvrA locus.",

keywords = "DNA damage, DNA repair, Excinuclease, Nucleotide excision",

author = "{De La Morena}, {Maria L.} and Hendrixson, {David R.} and {St. Geme}, {Joseph W.}",

year = "1996",

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doi = "10.1016/0378-1119(96)00264-8",

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T1 - Isolation and characterization of the Haemophilus influenzae uvrA gene

AU - De La Morena, Maria L.

AU - Hendrixson, David R.

AU - St. Geme, Joseph W.

PY - 1996/10/24

Y1 - 1996/10/24

N2 - The uvrA gene of Haemophilus influenzae (Hi) was cloned and sequenced. Analysis of the deduced amino acid sequence revealed 81% identity and 90% similarity with the Escherichia coli UvrA protein. Consistent with a role of Hi uvrA in DNA repair, a Hi uvrA mutant exhibited increased sensitivity of UV irradiation. Furthermore, Hi uvr A was able to complement a mutation in the E. coli uvrA locus.

AB - The uvrA gene of Haemophilus influenzae (Hi) was cloned and sequenced. Analysis of the deduced amino acid sequence revealed 81% identity and 90% similarity with the Escherichia coli UvrA protein. Consistent with a role of Hi uvrA in DNA repair, a Hi uvrA mutant exhibited increased sensitivity of UV irradiation. Furthermore, Hi uvr A was able to complement a mutation in the E. coli uvrA locus.

KW - DNA damage

KW - DNA repair

KW - Excinuclease

KW - Nucleotide excision

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SN - 0378-1119

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EP - 28

JO - Gene

JF - Gene

IS - 1-2

ER -

Isolation and characterization of the Haemophilus influenzae uvrA gene

Abstract

Keywords

ASJC Scopus subject areas

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