Intrathecal substance P-saporin for the treatment of intractable cancer pain

Hugh Nymeyer; Douglas A. Lappi; Denise Higgins; Carl E. Noe; Arthur E. Frankel

doi:10.1007/978-3-319-27607-6_13

Intrathecal substance P-saporin for the treatment of intractable cancer pain

Hugh Nymeyer, Douglas A. Lappi, Denise Higgins, Carl E. Noe, Arthur E. Frankel

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Substance P-saporin (SP-SAP) has covalent bonds between the biological toxin, saporin (SAP), and the endogenous peptide, substance P (SP). SAP targets the toxin to the subset of neurons expressing the NK1 receptor. SP-SAP is currently in a phase I clinical trial and is unique as it is the only targeted toxin for pain to undergo human testing. This chapter reviews the history of SP-SAP and related NK1-receptor targeted toxins, animal data on the safety and efficacy of SP-SAP for the treatment of pain (in light of the results of NK1 receptor antagonists and knockouts/knockdowns of either SP or the NK1 receptor), and mechanisms of action of SP-SAP.

Original language	English (US)
Title of host publication	Techniques of Neurolysis
Publisher	Springer International Publishing
Pages	197-206
Number of pages	10
ISBN (Electronic)	9783319276076
ISBN (Print)	9783319276052
DOIs	https://doi.org/10.1007/978-3-319-27607-6_13
State	Published - Jan 1 2016

Keywords

Allodynia pain
Hyperalgesia
NK1
SP-SAP
Substance p

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-3-319-27607-6_13

Cite this

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abstract = "Substance P-saporin (SP-SAP) has covalent bonds between the biological toxin, saporin (SAP), and the endogenous peptide, substance P (SP). SAP targets the toxin to the subset of neurons expressing the NK1 receptor. SP-SAP is currently in a phase I clinical trial and is unique as it is the only targeted toxin for pain to undergo human testing. This chapter reviews the history of SP-SAP and related NK1-receptor targeted toxins, animal data on the safety and efficacy of SP-SAP for the treatment of pain (in light of the results of NK1 receptor antagonists and knockouts/knockdowns of either SP or the NK1 receptor), and mechanisms of action of SP-SAP.",

keywords = "Allodynia pain, Hyperalgesia, NK1, SP-SAP, Substance p",

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AU - Nymeyer, Hugh

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AU - Higgins, Denise

AU - Noe, Carl E.

AU - Frankel, Arthur E.

PY - 2016/1/1

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N2 - Substance P-saporin (SP-SAP) has covalent bonds between the biological toxin, saporin (SAP), and the endogenous peptide, substance P (SP). SAP targets the toxin to the subset of neurons expressing the NK1 receptor. SP-SAP is currently in a phase I clinical trial and is unique as it is the only targeted toxin for pain to undergo human testing. This chapter reviews the history of SP-SAP and related NK1-receptor targeted toxins, animal data on the safety and efficacy of SP-SAP for the treatment of pain (in light of the results of NK1 receptor antagonists and knockouts/knockdowns of either SP or the NK1 receptor), and mechanisms of action of SP-SAP.

AB - Substance P-saporin (SP-SAP) has covalent bonds between the biological toxin, saporin (SAP), and the endogenous peptide, substance P (SP). SAP targets the toxin to the subset of neurons expressing the NK1 receptor. SP-SAP is currently in a phase I clinical trial and is unique as it is the only targeted toxin for pain to undergo human testing. This chapter reviews the history of SP-SAP and related NK1-receptor targeted toxins, animal data on the safety and efficacy of SP-SAP for the treatment of pain (in light of the results of NK1 receptor antagonists and knockouts/knockdowns of either SP or the NK1 receptor), and mechanisms of action of SP-SAP.

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Intrathecal substance P-saporin for the treatment of intractable cancer pain

Abstract

Keywords

ASJC Scopus subject areas

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