TY - JOUR
T1 - Intrapartum treatment of acute chorioamnionitis
T2 - Impact on neonatal sepsis
AU - Gilstrap, L. C.
AU - Leveno, K. J.
AU - Cox, S. M.
AU - Burris, J. S.
AU - Mashburn, M.
AU - Rosenfeld, C. R.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - In a study of 312 women with acute chorioamnionitis, 152 women received antibiotics before delivery, 90 received antibiotics after cord clamping, and 70 did not receive antibiotics. Antibiotics were administered during labor rather than after cord clamping if delivery was not imminent. Although endometritis developed more frequently in the patients receiving antibiotics after cord clamping, the difference was not statistically significant (5.6% versus 3.9%, difference not significant). There were two cases of verified sepsis in the group of infants (35 weeks) born to mothers receiving intrapartum antibiotics and there were eight cases in the no antibiotics group (p = 0.06). More importantly, in neonates ≥ 35 weeks' gestational age, there was a significant difference in the frequency of positive blood cultures for group B streptococci (0/133 versus 8/140, p < 0.05). We conclude that administration of antibiotics to the mother during labor may result in a decreased incidence of neonatal sepsis.
AB - In a study of 312 women with acute chorioamnionitis, 152 women received antibiotics before delivery, 90 received antibiotics after cord clamping, and 70 did not receive antibiotics. Antibiotics were administered during labor rather than after cord clamping if delivery was not imminent. Although endometritis developed more frequently in the patients receiving antibiotics after cord clamping, the difference was not statistically significant (5.6% versus 3.9%, difference not significant). There were two cases of verified sepsis in the group of infants (35 weeks) born to mothers receiving intrapartum antibiotics and there were eight cases in the no antibiotics group (p = 0.06). More importantly, in neonates ≥ 35 weeks' gestational age, there was a significant difference in the frequency of positive blood cultures for group B streptococci (0/133 versus 8/140, p < 0.05). We conclude that administration of antibiotics to the mother during labor may result in a decreased incidence of neonatal sepsis.
KW - Chorioamnionitis
KW - group B streptococci
KW - intrapartum antibiotics
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U2 - 10.1016/S0002-9378(88)80012-7
DO - 10.1016/S0002-9378(88)80012-7
M3 - Article
C2 - 3421256
AN - SCOPUS:0023766155
SN - 0002-9378
VL - 159
SP - 579
EP - 583
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 3
ER -