Intrahepatic Cholangiocarcinoma

George A. Poultsides; Andrew X. Zhu; Michael A. Choti; Timothy M. Pawlik

doi:10.1016/j.suc.2010.04.011

Intrahepatic Cholangiocarcinoma

George A. Poultsides, Andrew X. Zhu, Michael A. Choti, Timothy M. Pawlik

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

Abstract

Intrahepatic cholangiocarcinoma (ICC) is a primary cancer of the bile ducts, arising from malignant transformation of the epithelial cells that line the biliary apparatus. ICC is relatively uncommon, but its incidence is on the increase. ICC is frequently discovered as an incidental, indeterminate liver mass. Surgical resection of ICC represents the only potentially curative therapeutic option. The role of routine hilar lymphadenectomy is controversial, but should be considered to optimize staging. Although adjuvant chemotherapy and radiotherapy is probably not supported by current data, each should strongly be considered in patients with lymph node metastasis or an R1 resection. For those patients with inoperable disease, locoregional therapy with transarterial chemoembolization can be considered.

Original language	English (US)
Pages (from-to)	817-837
Number of pages	21
Journal	Surgical Clinics of North America
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/j.suc.2010.04.011
State	Published - Aug 2010

Keywords

Biliary cancer
Hepatectomy
Liver cancer
Liver resection
Peripheral cholangiocarcinoma

ASJC Scopus subject areas

Surgery

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10.1016/j.suc.2010.04.011

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title = "Intrahepatic Cholangiocarcinoma",

abstract = "Intrahepatic cholangiocarcinoma (ICC) is a primary cancer of the bile ducts, arising from malignant transformation of the epithelial cells that line the biliary apparatus. ICC is relatively uncommon, but its incidence is on the increase. ICC is frequently discovered as an incidental, indeterminate liver mass. Surgical resection of ICC represents the only potentially curative therapeutic option. The role of routine hilar lymphadenectomy is controversial, but should be considered to optimize staging. Although adjuvant chemotherapy and radiotherapy is probably not supported by current data, each should strongly be considered in patients with lymph node metastasis or an R1 resection. For those patients with inoperable disease, locoregional therapy with transarterial chemoembolization can be considered.",

keywords = "Biliary cancer, Hepatectomy, Liver cancer, Liver resection, Peripheral cholangiocarcinoma",

author = "Poultsides, {George A.} and Zhu, {Andrew X.} and Choti, {Michael A.} and Pawlik, {Timothy M.}",

year = "2010",

month = aug,

doi = "10.1016/j.suc.2010.04.011",

language = "English (US)",

volume = "90",

pages = "817--837",

journal = "Surgical Clinics of North America",

issn = "0039-6109",

publisher = "W.B. Saunders Ltd",

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}

TY - JOUR

T1 - Intrahepatic Cholangiocarcinoma

AU - Poultsides, George A.

AU - Zhu, Andrew X.

AU - Choti, Michael A.

AU - Pawlik, Timothy M.

PY - 2010/8

Y1 - 2010/8

N2 - Intrahepatic cholangiocarcinoma (ICC) is a primary cancer of the bile ducts, arising from malignant transformation of the epithelial cells that line the biliary apparatus. ICC is relatively uncommon, but its incidence is on the increase. ICC is frequently discovered as an incidental, indeterminate liver mass. Surgical resection of ICC represents the only potentially curative therapeutic option. The role of routine hilar lymphadenectomy is controversial, but should be considered to optimize staging. Although adjuvant chemotherapy and radiotherapy is probably not supported by current data, each should strongly be considered in patients with lymph node metastasis or an R1 resection. For those patients with inoperable disease, locoregional therapy with transarterial chemoembolization can be considered.

AB - Intrahepatic cholangiocarcinoma (ICC) is a primary cancer of the bile ducts, arising from malignant transformation of the epithelial cells that line the biliary apparatus. ICC is relatively uncommon, but its incidence is on the increase. ICC is frequently discovered as an incidental, indeterminate liver mass. Surgical resection of ICC represents the only potentially curative therapeutic option. The role of routine hilar lymphadenectomy is controversial, but should be considered to optimize staging. Although adjuvant chemotherapy and radiotherapy is probably not supported by current data, each should strongly be considered in patients with lymph node metastasis or an R1 resection. For those patients with inoperable disease, locoregional therapy with transarterial chemoembolization can be considered.

KW - Biliary cancer

KW - Hepatectomy

KW - Liver cancer

KW - Liver resection

KW - Peripheral cholangiocarcinoma

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DO - 10.1016/j.suc.2010.04.011

M3 - Review article

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AN - SCOPUS:77954641348

SN - 0039-6109

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JO - Surgical Clinics of North America

JF - Surgical Clinics of North America

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ER -

Intrahepatic Cholangiocarcinoma

Abstract

Keywords

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