Intrahepatic Cholangiocarcinoma

George A. Poultsides, Andrew X. Zhu, Michael A. Choti, Timothy M. Pawlik

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations


Intrahepatic cholangiocarcinoma (ICC) is a primary cancer of the bile ducts, arising from malignant transformation of the epithelial cells that line the biliary apparatus. ICC is relatively uncommon, but its incidence is on the increase. ICC is frequently discovered as an incidental, indeterminate liver mass. Surgical resection of ICC represents the only potentially curative therapeutic option. The role of routine hilar lymphadenectomy is controversial, but should be considered to optimize staging. Although adjuvant chemotherapy and radiotherapy is probably not supported by current data, each should strongly be considered in patients with lymph node metastasis or an R1 resection. For those patients with inoperable disease, locoregional therapy with transarterial chemoembolization can be considered.

Original languageEnglish (US)
Pages (from-to)817-837
Number of pages21
JournalSurgical Clinics of North America
Issue number4
StatePublished - Aug 2010


  • Biliary cancer
  • Hepatectomy
  • Liver cancer
  • Liver resection
  • Peripheral cholangiocarcinoma

ASJC Scopus subject areas

  • Surgery


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