Intradural Cauda Equina Metastases: A Systematic Review of Clinico-radiological Features, Management, and Treatment Outcomes

Paolo Palmisciano; Saif E. Zaidi; Nathan A. Shlobin; Navraj S. Sagoo; Othman B.I.N. Alamer; Gianluca Scalia; Gianluca Ferini; Giuseppe E. Umana; Salah G. Aoun; Ali S. Haider

doi:10.21873/anticanres.15643

Intradural Cauda Equina Metastases: A Systematic Review of Clinico-radiological Features, Management, and Treatment Outcomes

Paolo Palmisciano, Saif E. Zaidi, Nathan A. Shlobin, Navraj S. Sagoo, Othman B.I.N. Alamer, Gianluca Scalia, Gianluca Ferini, Giuseppe E. Umana, Salah G. Aoun, Ali S. Haider

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Background/Aim: Intradural cauda equina metastases (ICEM) are rare tumors that reduce functional status. Surgery and radiation are feasible and effective treatments but may have debilitating complications. We systematically reviewed the literature on ICEMs. Materials and Methods: PubMed, Scopus, Web of Science, and Cochrane were searched for studies reporting clinical data of patients with ICEMs. Clinical characteristics, management strategies, and treatment outcomes were analyzed. Results: We included 40 studies comprising 123 patients. Median age was 57 years. The most frequent primary tumors were lung (18.7%), breast (13%), and renal carcinomas (11.4%). Median time from primary tumor diagnosis to ICEMs’ presentation was 36 months.

Original language	English (US)
Pages (from-to)	1661-1669
Number of pages	9
Journal	Anticancer Research
Volume	42
Issue number	4
DOIs	https://doi.org/10.21873/anticanres.15643
State	Published - Apr 2022

Keywords

Cauda equina
intradural metastases
spine metastases
spine oncology
systematic review

ASJC Scopus subject areas

Oncology
Cancer Research

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10.21873/anticanres.15643

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@article{9071bcf36c9c486c9edc29b66f564239,

title = "Intradural Cauda Equina Metastases: A Systematic Review of Clinico-radiological Features, Management, and Treatment Outcomes",

abstract = "Background/Aim: Intradural cauda equina metastases (ICEM) are rare tumors that reduce functional status. Surgery and radiation are feasible and effective treatments but may have debilitating complications. We systematically reviewed the literature on ICEMs. Materials and Methods: PubMed, Scopus, Web of Science, and Cochrane were searched for studies reporting clinical data of patients with ICEMs. Clinical characteristics, management strategies, and treatment outcomes were analyzed. Results: We included 40 studies comprising 123 patients. Median age was 57 years. The most frequent primary tumors were lung (18.7%), breast (13%), and renal carcinomas (11.4%). Median time from primary tumor diagnosis to ICEMs{\textquoteright} presentation was 36 months.",

keywords = "Cauda equina, intradural metastases, spine metastases, spine oncology, systematic review",

author = "Paolo Palmisciano and Zaidi, {Saif E.} and Shlobin, {Nathan A.} and Sagoo, {Navraj S.} and Alamer, {Othman B.I.N.} and Gianluca Scalia and Gianluca Ferini and Umana, {Giuseppe E.} and Aoun, {Salah G.} and Haider, {Ali S.}",

year = "2022",

month = apr,

doi = "10.21873/anticanres.15643",

language = "English (US)",

volume = "42",

pages = "1661--1669",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "4",

}

TY - JOUR

T1 - Intradural Cauda Equina Metastases

T2 - A Systematic Review of Clinico-radiological Features, Management, and Treatment Outcomes

AU - Palmisciano, Paolo

AU - Zaidi, Saif E.

AU - Shlobin, Nathan A.

AU - Sagoo, Navraj S.

AU - Alamer, Othman B.I.N.

AU - Scalia, Gianluca

AU - Ferini, Gianluca

AU - Umana, Giuseppe E.

AU - Aoun, Salah G.

AU - Haider, Ali S.

PY - 2022/4

Y1 - 2022/4

N2 - Background/Aim: Intradural cauda equina metastases (ICEM) are rare tumors that reduce functional status. Surgery and radiation are feasible and effective treatments but may have debilitating complications. We systematically reviewed the literature on ICEMs. Materials and Methods: PubMed, Scopus, Web of Science, and Cochrane were searched for studies reporting clinical data of patients with ICEMs. Clinical characteristics, management strategies, and treatment outcomes were analyzed. Results: We included 40 studies comprising 123 patients. Median age was 57 years. The most frequent primary tumors were lung (18.7%), breast (13%), and renal carcinomas (11.4%). Median time from primary tumor diagnosis to ICEMs’ presentation was 36 months.

AB - Background/Aim: Intradural cauda equina metastases (ICEM) are rare tumors that reduce functional status. Surgery and radiation are feasible and effective treatments but may have debilitating complications. We systematically reviewed the literature on ICEMs. Materials and Methods: PubMed, Scopus, Web of Science, and Cochrane were searched for studies reporting clinical data of patients with ICEMs. Clinical characteristics, management strategies, and treatment outcomes were analyzed. Results: We included 40 studies comprising 123 patients. Median age was 57 years. The most frequent primary tumors were lung (18.7%), breast (13%), and renal carcinomas (11.4%). Median time from primary tumor diagnosis to ICEMs’ presentation was 36 months.

KW - Cauda equina

KW - intradural metastases

KW - spine metastases

KW - spine oncology

KW - systematic review

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U2 - 10.21873/anticanres.15643

DO - 10.21873/anticanres.15643

M3 - Review article

C2 - 35346985

AN - SCOPUS:85127253205

SN - 0250-7005

VL - 42

SP - 1661

EP - 1669

JO - Anticancer Research

JF - Anticancer Research

IS - 4

ER -

Intradural Cauda Equina Metastases: A Systematic Review of Clinico-radiological Features, Management, and Treatment Outcomes

Abstract

Keywords

ASJC Scopus subject areas

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