TY - JOUR
T1 - Intracellular Toll-like Receptors
AU - Blasius, Amanda L.
AU - Beutler, Bruce
N1 - Funding Information:
We are grateful to E.M. Moresco for her critical reading of this paper and assistance in its preparation. This work was supported by NIH grant P01 AI070167 and NIH Contract HHSN272200700038C. A.L.B. is supported by The Irvington Institute Fellowship Program of the Cancer Research Institute.
PY - 2010/3
Y1 - 2010/3
N2 - Foreign nucleic acids, the signature of invading viruses and certain bacteria, are sensed intracellularly. The nucleic acid-specific Toll-like receptors (TLRs) detect and signal within endolysosomal compartments, triggering the induction of cytokines essential for the innate immune response. These cytokines include proinflammatory molecules produced mainly by macrophages and conventional dendritic cells, as well as type I interferons, which are produced in great quantities by plasmacytoid dendritic cells. The cellular and molecular pathways by which nucleic acids and TLRs meet within the endosome assure host protection yet also place the host at risk for the development of autoimmunity. Here, we review the latest findings on the intracellular TLRs, with special emphasis on ligand uptake, receptor trafficking, signaling, and regulation.
AB - Foreign nucleic acids, the signature of invading viruses and certain bacteria, are sensed intracellularly. The nucleic acid-specific Toll-like receptors (TLRs) detect and signal within endolysosomal compartments, triggering the induction of cytokines essential for the innate immune response. These cytokines include proinflammatory molecules produced mainly by macrophages and conventional dendritic cells, as well as type I interferons, which are produced in great quantities by plasmacytoid dendritic cells. The cellular and molecular pathways by which nucleic acids and TLRs meet within the endosome assure host protection yet also place the host at risk for the development of autoimmunity. Here, we review the latest findings on the intracellular TLRs, with special emphasis on ligand uptake, receptor trafficking, signaling, and regulation.
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U2 - 10.1016/j.immuni.2010.03.012
DO - 10.1016/j.immuni.2010.03.012
M3 - Review article
C2 - 20346772
AN - SCOPUS:77949940198
SN - 1074-7613
VL - 32
SP - 305
EP - 315
JO - Immunity
JF - Immunity
IS - 3
ER -