Intestinal stem cells in the adult Drosophila midgut

Huaqi Jiang; Bruce A. Edgar

doi:10.1016/j.yexcr.2011.07.020

Intestinal stem cells in the adult Drosophila midgut

Huaqi Jiang, Bruce A. Edgar

Research output: Contribution to journal › Review article › peer-review

135 Scopus citations

Abstract

Drosophila has long been an excellent model organism for studying stem cell biology. Notably, studies of Drosophila's germline stem cells have been instrumental in developing the stem cell niche concept. The recent discovery of somatic stem cells in adult Drosophila, particularly the intestinal stem cells (ISCs) of the midgut, has established Drosophila as an exciting model to study stem cell-mediated adult tissue homeostasis and regeneration. Here, we review the major signaling pathways that regulate the self-renewal, proliferation and differentiation of Drosophila ISCs, discussing how this regulation maintains midgut homeostasis and mediates regeneration of the intestinal epithelium after injury.

Original language	English (US)
Pages (from-to)	2780-2788
Number of pages	9
Journal	Experimental Cell Research
Volume	317
Issue number	19
DOIs	https://doi.org/10.1016/j.yexcr.2011.07.020
State	Published - Nov 15 2011

Keywords

Drosophila midgut
Intestinal stem cell
Tissue homeostasis
Tissue regeneration

ASJC Scopus subject areas

Cell Biology

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10.1016/j.yexcr.2011.07.020

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title = "Intestinal stem cells in the adult Drosophila midgut",

abstract = "Drosophila has long been an excellent model organism for studying stem cell biology. Notably, studies of Drosophila's germline stem cells have been instrumental in developing the stem cell niche concept. The recent discovery of somatic stem cells in adult Drosophila, particularly the intestinal stem cells (ISCs) of the midgut, has established Drosophila as an exciting model to study stem cell-mediated adult tissue homeostasis and regeneration. Here, we review the major signaling pathways that regulate the self-renewal, proliferation and differentiation of Drosophila ISCs, discussing how this regulation maintains midgut homeostasis and mediates regeneration of the intestinal epithelium after injury.",

keywords = "Drosophila midgut, Intestinal stem cell, Tissue homeostasis, Tissue regeneration",

author = "Huaqi Jiang and Edgar, {Bruce A.}",

note = "Funding Information: We thank Alexander Kohlmaier for Fig. 1 A and Jeffrey Rosa for comments. B.A.E was supported by NIH grant GM51186 , the European Research Council , and the DKFZ .",

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AU - Jiang, Huaqi

AU - Edgar, Bruce A.

N1 - Funding Information: We thank Alexander Kohlmaier for Fig. 1 A and Jeffrey Rosa for comments. B.A.E was supported by NIH grant GM51186 , the European Research Council , and the DKFZ .

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N2 - Drosophila has long been an excellent model organism for studying stem cell biology. Notably, studies of Drosophila's germline stem cells have been instrumental in developing the stem cell niche concept. The recent discovery of somatic stem cells in adult Drosophila, particularly the intestinal stem cells (ISCs) of the midgut, has established Drosophila as an exciting model to study stem cell-mediated adult tissue homeostasis and regeneration. Here, we review the major signaling pathways that regulate the self-renewal, proliferation and differentiation of Drosophila ISCs, discussing how this regulation maintains midgut homeostasis and mediates regeneration of the intestinal epithelium after injury.

AB - Drosophila has long been an excellent model organism for studying stem cell biology. Notably, studies of Drosophila's germline stem cells have been instrumental in developing the stem cell niche concept. The recent discovery of somatic stem cells in adult Drosophila, particularly the intestinal stem cells (ISCs) of the midgut, has established Drosophila as an exciting model to study stem cell-mediated adult tissue homeostasis and regeneration. Here, we review the major signaling pathways that regulate the self-renewal, proliferation and differentiation of Drosophila ISCs, discussing how this regulation maintains midgut homeostasis and mediates regeneration of the intestinal epithelium after injury.

KW - Drosophila midgut

KW - Intestinal stem cell

KW - Tissue homeostasis

KW - Tissue regeneration

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Intestinal stem cells in the adult Drosophila midgut

Abstract

Keywords

ASJC Scopus subject areas

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