@article{c993b8edda82495ea85a770e21a9dce7,
title = "Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis",
abstract = "Several steps of the HDL-mediated reverse cholesterol transport (RCT) are transcriptionally regulated by the nuclear receptors LXRs in the macrophages, liver, and intestine. Systemic LXR activation via synthetic ligands induces RCT but also causes increased hepatic fatty acid synthesis and steatosis, limiting the potential therapeutic use of LXR agonists. During the last few years, the participation of the intestine in the control of RCT has appeared more evident. Here we show that while hepaticspecific LXR activation does not contribute to RCT, intestinal-specific LXR activation leads to decreased intestinal cholesterol absorption, improved lipoprotein profile, and increased RCT in vivo in the absence of hepatic steatosis. These events protect against atherosclerosis in the background of the LDLR-deficient mice. Our study fully characterizes the molecular and metabolic scenario that elects the intestine as a key player in the LXR-driven protective environment against cardiovascular disease.",
author = "Sasso, {Giuseppe Lo} and Stefania Murzilli and Lorena Salvatore and Ilenia D'Errico and Michele Petruzzelli and Paola Conca and Jiang, {Zhao Yan} and Laura Calabresi and Paolo Parini and Antonio Moschetta",
note = "Funding Information: We thank V. Cardile, A.K. Groen, D. Gumucio, D.J. Mangelsdorf, G. Palasciano, G. Tognoni, and G. Villani for tools and discussion; Telethon Core Facility for Conditional Mutagenesis at the Istituto Scientifico San Raffaele (Milano) for generating transgenic mice; R. Ledonne, G. Di Tullio, A. D'Orazio, and C. Di Filippo for technical assistance. This work was funded by Italian Ministry of Health and Education (Finanziamenti per la Ricerca di Base -IDEAS- RBID08C9N7), Italian Association for Cancer Research (AIRC, Milan, Italy), European Community's Seventh Framework Programme FP7/2007– 013 under Grant Agreement No. 202272 (LipidomicNet), Telethon Foundation (GPP08259), Cariplo Foundation Milan, University of Bari, Italy. S.M. is a fellow of CariSPAQ (L'Aquila, Italy). G.L.S. is a fellow of AIRC (Milan, Italy). ",
year = "2010",
month = aug,
day = "4",
doi = "10.1016/j.cmet.2010.07.002",
language = "English (US)",
volume = "12",
pages = "187--193",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "2",
}