Interplay of tumor vascular oxygenation and pO 2 in tumors using NIRS and needle electrode

Gwan Kim Jae Gwan Kim, Y. Song, D. Zhao, A. Constantinescu, R. P. Mason, H. Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


The effective measurement of dynamic changes of blood and tissue oxygenation of tumors could be valuable for optimizing tumor treatment plans. For this study, a near-infrared spectroscopy system and pO 2 needle electrode were used to measure simultaneously changes in total hemoglobin concentration ([Hb] total), oxygenated hemoglobin concentration ([HBO 2]) and local oxygen tension (pO 2) in the vascular bed of prostate tumors implanted in rats in response to respiratory challenge. The inhaled gas was alternated between air and carbogen (95% oxygen, 5% CO 2). Significant changes in tumor vascular oxygenation were observed with an apparent threshold for variation in [HbO 2]/[HbO 2] max. For comparison, a phantom study was undertaken with 1% intralipid solution and blood. The slope of [HbO 2]/[HbO 2] max vs. pO 2 in the phantom was ten times larger than in the tumor indicating that tumor cells are relatively resistant to oxygenation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive approach to monitoring tumor physiology and is compatible with additional techniques.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsB. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraka
Number of pages8
StatePublished - 2001
EventOptical Tomography and Spectroscopy of Tissue IV - San Jose, CA, United States
Duration: Jan 21 2001Jan 23 2001


OtherOptical Tomography and Spectroscopy of Tissue IV
Country/TerritoryUnited States
CitySan Jose, CA


  • Frequency-domain spectroscopy
  • NIR spectroscopy
  • pO electrode
  • Tumor vascular oxygenation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics


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